Supporting your patients and your practice

Heron Connect® offers programs to help ensure SUSTOL® is financially accessible for your patients. Services are also provided to help streamline the access process for your practice.

Select the program and enrollment path that best meets the needs of individual patients.

Heron Connect Copay Assistance Program*

Commercially insured patients can benefit from $0 out-of-pocket costs for SUSTOL with the availability of copay assistance from Heron Therapeutics. When applicable, patients may also be eligible for deductible assistance up to $200 per treatment. You can enroll your patients in the following ways:

To verify benefits and enroll your patients:

Download and complete the Insurance Verification and Program Enrollment Form. Fax form to 1-844-504-8652.

Practices that verify benefits directly can use simplified registration:

Enroll your patients online.


First, complete a one-time Practice Copay Assistance Program Enrollment Form. Once the practice enrollment form is complete, individual patients can then be enrolled by completing the Patient Copay Assistance Program Registration Form. Fax forms to 1-844-504-8652.

Heron Connect Patient Assistance Program

Eligible patients may choose to enroll in the Heron Connect Patient Assistance Program (PAP). This program is for patients with financial hardship who meet program eligibility criteria to receive SUSTOL at no cost.

To verify benefits and enroll your patients:

Complete the Insurance Verification and Program Enrollment Form. Fax this form and the prescription for SUSTOL to 1-844-504-8652.

Heron Commitment Program®‡

Heron Therapeutics is dedicated to ensuring patients and providers have access to SUSTOL. The Heron Commitment Program helps mitigate the economic burden of denials; in the event of a qualifying claim denial,§ the program will credit your practice for the cost of the administered medication, when program requirements are met.

More information on this program is available here.

To enroll your practice:

Complete a one-time Heron Commitment Program Enrollment Form. Fax this form to 1-844-504-8652.

Heron Connect services provide the access solutions you need

  • Dedicated Reimbursement Counselors: Your counselor will be a single point of contact for your practice
    • Help patients with enrollment in Heron Connect programs and insurance verification
    • Assist with prior authorization, appeals, billing, reimbursement, and coding
    • Track outcomes, and provide other services to support patients and help them secure product coverage
  • Prior Authorization and Appeals Support: Sample forms and letters are also available for download
  • Drug Replacement: In the event that SUSTOL is determined to be unfit for patient use, or has expired, Heron Therapeutics will replace the affected units. Call Heron Connect for more information at 1-844-HERON11 (1-844-437-6611)||
  • Product Information: Call if you have a clinical inquiry or would like to report an adverse event related to SUSTOL

For more information on Heron Connect, call 1-844-HERON11 (1-844-437-6611) from 8 am to 5 pm ET, Monday through Friday.

  1. Limitations apply. Offer not valid as follows: (a) patients covered under Medicare, Medicaid, or any federal or state program; (b) where plan covers treatment for the patient for the entire cost of the prescription drug. Patients pay $0 per copay per dose per 12-month calendar period. When applicable, deductible assistance up to $200 per treatment will be covered. For cash-paying patients, the program will cover $150 per prescription up to $1,800 per calendar year. Eligibility is for 12 months, after which patient will need to reapply for continued assistance. This offer expires 12/31/23.
  2. Heron Therapeutics, Inc., reserves the right, at its sole discretion, to discontinue the Heron Connect Patient Assistance Program or change the qualifications at any time. All patient information remains confidential. Product supply for the program depends on availability.
  3. The Heron Commitment Program and the other product support programs offered by Heron Therapeutics do not impose any purchase obligation at any time or in any manner. Use of CINVANTI and/or SUSTOL may be discontinued at any time, without penalty.
  4. A qualifying claim denial can be reviewed for the Heron Commitment Program when, for a patient covered under commercial insurance, the following criteria have been met, and documentation confirms: (a) the verification of benefits, conducted by the provider and/or Heron Connect, meets all of the payer criteria and/or policy requirements, (b) the submitted claim for the Heron product is denied, and (c) the claim has been denied again by the commercial payer after the first level of appeals process has been followed.
  5. Determination will be made by the manufacturer of SUSTOL.


SUSTOL is indicated in combination with other antiemetics in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy (MEC) or anthracycline and cyclophosphamide (AC) combination chemotherapy regimens.



SUSTOL is contraindicated in patients with hypersensitivity to granisetron, any of the components of SUSTOL, or any other 5-HT3 receptor antagonist.

Warnings and Precautions

Injection site reactions (ISRs), including infection, bleeding, pain and tenderness, nodules, swelling, and induration, have occurred with SUSTOL. Monitor for ISRs following SUSTOL injection. Inform patients that some ISRs may occur 2 weeks or more after SUSTOL administration. In patients receiving antiplatelet agents or anticoagulants, consider the increased risk of bruising or severe hematoma prior to the use of SUSTOL.

Monitor for constipation and decreased bowel activity and consider optimizing patients’ current bowel regimens used for managing preexisting constipation. Instruct patients to seek immediate medical care if signs and symptoms of ileus occur.

Hypersensitivity reactions have been reported and may occur up to 7 days or longer following SUSTOL administration and may have an extended course. If a reaction occurs, administer appropriate treatment and monitor until signs and symptoms resolve.

Serotonin syndrome has been reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs.

Use in Specific Populations

Avoid SUSTOL in patients with severe renal impairment. In patients with moderate renal impairment, administer SUSTOL not more frequently than once every 14 days.

Adverse Reactions

Most common adverse reactions (≥3%) are injection site reactions, constipation, fatigue, headache, diarrhea, abdominal pain, insomnia, dyspepsia, dizziness, asthenia, and gastroesophageal reflux.

Report side effects to the FDA at 1-800-FDA-1088 or Report side effects to Heron at 1-844-437-6611.

Please see full Prescribing Information including Medication Guide or visit